Sully points us to an interesting blog post on the decline of St. Louis courtesy of the interstate highway system. There is, unfortunately, a whole lot of truth to this.
St. Louis is a fascinating town. It is very old, considerably older than most other cities west of the Mississippi. Geographically it's almost a southern city but no one from the area would dare refer to St. Louis as a Southern town. It has a long standing history of sharp racial divisions. The city itself (the city and county are entirely separate entities) has a political system from when it had 3,000,000 residents, not 275,000 - which leads to almost total political gridlock. I could go on and on, someone should write a book.